Annotation A scholarly edition of a work by Adam Smith. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

The comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain. Neuroimaging research has shown that chronic pain and opioid dependence both affect brain structure and function, but this is the first study to evaluate the neurophysiological alterations in patients with comorbid chronic pain and addiction. Eighteen participants with chronic low back pain and opioid addiction were compared with eighteen age- and sex-matched healthy individuals in a (...) pain-induction fMRI task. Unified structural equation modeling (SEM) with Lagrange multiplier (LM) testing yielded a network model of pain processing for patient and control groups based on 19 a priori defined regions. Tests of differences between groups on specific regression parameters were determined on a path-by-path basis using z-tests corrected for the number of comparisons. Patients with the chronic pain and addiction comorbidity had increased connection strengths; many of these connections were interhemispheric and spanned regions involved in sensory, affective, and cognitive processes. The affected regions included those that are commonly altered in chronic pain or addiction alone, indicating that this comorbidity manifests with neurological symptoms of both disorders. Understanding the neural mechanisms involved in the comorbidity is crucial to finding a comprehensive treatment, rather than treating the symptoms individually. (shrink)

Cancer and its treatment pose challenges that affect not only patients but also their significant others, including intimate partners. Accumulating evidence suggests that couples’ ability to communicate effectively plays a major role in the psychological adjustment of both individuals and the quality of their relationship. Two key conceptual models have been proposed to account for how couple communication impacts psychological and relationship adjustment: the social-cognitive processing (SCP) model and the relationship intimacy (RI) model. These models posit different mechanisms and outcomes, (...) and thus have different implications for intervention. The purpose of this project is to test and compare the utility of these models using comprehensive and methodologically rigorous methods. Aims are: (1) to examine the overall fit of the SCP and RI models in explaining patient and partner psychological and relationship adjustment as they occur on a day-to-day basis and over the course of 1 year; (2) to examine the fit of the models for different subgroups (males vs. females, and patients vs. partners); and (3) to examine the utility of various methods of assessing communication by examining the degree to which baseline indices from different measurement strategies predict self-reported adjustment at 1-year follow up. The study employs a longitudinal, multi-method approach to examining communication processes including: standard self-report questionnaires assessing process and outcome variables collected quarterly over the course of 1 year; smartphone-based ecological momentary assessments to sample participant reports in real time; and laboratory-based couple conversations from which we derive observational measures of communicative behavior and affective expression, as well as vocal indices of emotional arousal. Participants are patients with stage II-IV breast, colon, rectal, or lung cancer and their spouses/partners, recruited from two NCI-designated comprehensive cancer centers. Results will be published in scientific journals, presented at scientific conferences, and conveyed to a larger audience through infographics and social media outlets. Findings will inform theory, measurement, and the design and implementation of efficacious interventions aimed at optimizing both patient and partner well-being. (shrink)

Female coital orgasm may be an adaptation for preferentially retaining the sperm of males with “good genes.” One indicator of good genes may be physical attractiveness. Accordingly, R. Thornhill, S. W. Gangestad, and R. Comer (1995) found that women mated to more attractive men reported an orgasm during a greater proportion of copulations than did women mated to less attractive men. The current research replicates this finding, with several design variations. We collected self-report data from 388 women residing in the (...) United States or in Germany. Results support the hypothesis that women mated to more attractive men are more likely to report an orgasm at the most recent copulation than are women mated to less attractive men, after statistically controlling for several key variables. Discussion addresses (a) the inability of the present research to specify the causal link between female orgasm and male attractiveness and (b) the proactive nature of female sexuality documented in recent research guided by an evolutionary perspective. (shrink)

Principled discussions of civil rights became inherently less likely as a direct result of the observation by Earl Warren, in Brown v. Board of Education, that, respecting freedmen, “Education of Negroes was almost non-existent, and practically all of the race were illiterate,” and in proportion as that observation increasingly became the foundation of common opinion on the subject. Warren's observation was not true in any meaningful or non-trivial sense. Nevertheless, it served to perpetuate the myth of a backward people needing (...) help to catch up instead of the truth of a people being held back. That is the perspective – the disadvantaged group perspective – that ultimately infected all discussion of civil rights, even after the designation of so-called “disadvantaged groups” had been extended beyond American blacks. To define civil rights, we may well begin with what all mankind would likely recognize. Thus the dictionary definition of “civil rights” stands: “the rights that belong to all individuals in a nation or community touching property, marriage, and the like.” In that definition the term “rights” may be further expanded to mean “legitimate claims,” following the definition of right as law – as “a claim or title or interest in anything whatever that is enforceable by law.” This definition applies with minimal distinction of regimes intruding and, therefore, without the host of recent complications in the United States that create the impression that civil rights have something to do with pluralism. Previously, the generic definition was thought to exhaust the meaning of the term in the United States. (shrink)

In this issue of the American Journal of Bioethics, manuscripts focus on the obligations of clinicians and researchers in pragmatic clinical trials (Garland, Morain, and Sugarman 2023; Morain and L...

"Bibliographical notes": pages [243]-244.

Everyone knows the statement of Servius that Virgil was compelled by Augustus to alter the second half of the Fourth Georgic after the fall of Gallus, and that he substituted the story of Aristaeus for the laudes Galli. This statement, often doubted by older generations, has had such a remarkable success in recent years that anyone who ventures to impugn it must feel that he is pleading with a halter round his neck before a one-sided jury. It is notable, however, (...) that these jurors, though one-sided, are by no means united, save in their determination to uphold the credit of Servius. One group will assure us that the episode of Aristaeus shows obvious signs not only of haste but of immaturity, and they draw a pathetic picture of the grief-stricken Virgil, ordered to bring out a second edition minus the praises of his friend Gallus, and half-heartedly throwing together some bits of juvenile stuff which he happened to have handy. Others assure us that the tale of Aristaeus shows us a more mature Virgil, nearer to the Virgil of the Aeneid. But the Servians really cannot have it both ways. They must make up their minds in the one direction or in the other if they are to be taken seriously. They make it doubly difficult for us to take them seriously when they try to tell us what Servius meant—but of that more anon. The present paper is an attempt by a converted Servian to examine frankly the arguments which have been advanced in support of Servius. Most of these may be found in Skutsch, Aus Vergils Frühzeit, pp. 140–147. One is very reluctant to use disparaging words about an eminent scholar who has served the cause of learning in so many ways; but it can scarcely be denied that the work just mentioned, in spite of its ingenuity and enthusiasm, shows a lamentable lack of three great essentials—a judicial temper, accurate statement of facts, and cogent reasoning. There is also at times a regrettable vagueness of expression, suggesting that the author is concealing inward doubts or shrinking from thought. All these deficiencies are to some extent present in the section with which this paper is concerned. (shrink)

D. D. Raphael and A. L. Macfie (1976) II An Inquiry into the Nature and Causes of the Wealth of Nations, ed. R. H. Campbell and A. S. Skinner; textual editor W. B. Todd, 2 vols. (1976) III Essays on Philosophical Subjects, ed. W. P. D. Wightman  ...

The late Jacob Klein’s important book is, remarkably, a lucid presentation of esoteric argument. Dealing with the famed Platonic triad, Theaetetus, Sophist, and Statesman, Klein settles the dispute about the missing dialogue, "The Philosopher," by first denying that it is missing and second showing that it is unnecessary. He argues, in short, that the triad is a dyad. That argument is reinforced by the distinction Klein strongly implies between the Socratic Theaetetus and the Eleatic Sophist and Statesman. "We can now (...) understand why the conversations of the ‘trilogy’ occur in two, not three, days and why the Sophist, the Statesman, and the Philosopher are dealt with in two, not three, dialogues". (shrink)

The subject of these lines may be found in Caes. B.C. I. 54, from which they are in part derived, though probably at second hand. The reference is to Caesar's tactics after the floods in the plain around Ilerda. He built a number of coracles after the British fashion, and had them conveyed to a point on the right bank of the Sicoris, twenty-two miles from his camp. In these boats he sent a number of men across the river, who (...) fortified some rising ground. Then he sent a legion across and started the building of a bridge from both sides at once: hue legionem postea traiecit atque ex utraque parte pontem institutum biduo perfecit. (shrink)

This well-known passage refers to the growth of latifundia, a symptom of Rome's decadence. In v. 170 ignotis is generally taken to mean ‘unknown to the owners,’ and thus, it seems to me, the point of the passage is missed. There is a double antithesis; longa is contrasted with breuίa, parua, and ίgnotίs with notίs, ίnlustrίbus, or the like. The latter antithesis is implied in Camίllί, Curίorum; the other is left to be understood. In the good old days farms were (...) small, but were cultivated by the most eminent citizens, men like Camillus and Curius Dentatus; now these small farms are combined to form latίfundίa, managed by nobodies , whether slaves or tenant farmers. The juxta-position of longa and sub ίgnotίs is intentional. (shrink)

Hosius and others have suspected v. 87 on the ground that it is omitted by most of the good MSS. But the omission, as Weber saw, is due to the similar endings of vv. 86–87. It is difficult to see how a student of Lucan could convince himself that any other person is the author of v. 87, which not only improves the passage, but is wholly in keeping with the gloomy fatalism of Pompey as represented by Lucan in many (...) other places. Francken's objection that the emphatic me should have a pronoun contrasted with it may be sufficiently answered by a reference to vv. 396–398 of the same book; many instances from other authors could be added. (shrink)

The Thebaid, with all its faults, deserves more attention than it generally receives in these days; it is something more than a desirable quarry for ‘unseens.’ Its exegesis is in a very backward state, quite unworthy of modern scholarship. It is almost a hundred years since the last explanatory edition was published, and the commentators on Statius have, as a rule, been more remarkable for their learning than for their discernment. Before the appearance of the Oxford edition and the latest (...) Teubner recension the materials for the establishment of the text were very defective; and in spite of the valuable labours of Messrs. Garrod and Klotz , the Thebaid still offers considerable scope for the textual critic. The MSS. present many puzzles; it must also be confessed that in not a few places the work of scholars in the last century has done more harm than good. The following notes on Book II., whatever their value, may perhaps help to call attention to the need for more labourers in a promising field. (shrink)

The Thebaid, with all its faults, deserves more attention than it generally receives in these days; it is something more than a desirable quarry for ‘unseens.’ Its exegesis is in a very backward state, quite unworthy of modern scholarship. It is almost a hundred years since the last explanatory edition was published, and the commentators on Statius have, as a rule, been more remarkable for their learning than for their discernment. Before the appearance of the Oxford edition and the latest (...) Teubner recension the materials for the establishment of the text were very defective; and in spite of the valuable labours of Messrs. Garrod and Klotz, the Thebaid still offers considerable scope for the textual critic. The MSS. present many puzzles; it must also be confessed that in not a few places the work of scholars in the last century has done more harm than good. The following notes on Book II., whatever their value, may perhaps help to call attention to the need for more labourers in a promising field. (shrink)

The passage is thought to refer to the efforts of the Macedonians to honour the memory of their dead king. Who are meant by reges is not at all clear, and summa nituntur opum ui, as we may infer from other passages where the same or a similar expression is used, can hardly refer to anything but the labour of the hands. Probably we ought to read regis, i.e. Philippi. The lines will then refer to the work of the people.

The passage is thought to refer to the efforts of the Macedonians to honour the memory of their dead king. Who are meant by reges is not at all clear, and summa nituntur opum ui, as we may infer from other passages where the same or a similar expression is used, can hardly refer to anything but the labour of the hands. Probably we ought to read regis, i.e. Philippi. The lines will then refer to the work of the people.

This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

The subject of these lines may be found in Caes. B.C. I. 54, from which they are in part derived, though probably at second hand. The reference is to Caesar's tactics after the floods in the plain around Ilerda. He built a number of coracles after the British fashion, and had them conveyed to a point on the right bank of the Sicoris, twenty-two miles from his camp. In these boats he sent a number of men across the river, who (...) fortified some rising ground. Then he sent a legion across and started the building of a bridge from both sides at once: hue legionem postea traiecit atque ex utraque parte pontem institutum biduo perfecit. (shrink)

It would be natural to expect, after all these years, that the language of an author so important as Livy would be adequately represented in the dictionaries. Unfortunately this is very far from being the case. It is disquieting to find numerous Livian words cited without any mention of Livy or of any other writer of the Ciceronian or the Augustan Age. It is equally disquieting to find Livian idioms or constructions attributed only to writers remote from Livy both in (...) time and in genre. To crown all, we find a good many of Livy's notable usages entirely ignored. Perhaps a humble service may be rendered both to Livy and to the history of the Latin language by indicating a few deficiencies, especially in the parts of the alphabet not yet covered by the Thesaurus Linguae Latinae. (shrink)